書誌事項
- タイトル別名
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- Autologous Tumor-specific Immunotherapy for Recurrent Malignant Melanoma of the Nasal Cavity
- サイハツ ビクウ アクセイ コクショク シュ ニ タイスル サイボウ メンエキ リョウホウ
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説明
Malignant melanoma usually occurs in tissues containing large numbers of melanocytes, such as the skin, mucosa and eye, and is one of the most highly malignant tumors known. No satisfactory treatment results have ever been reported. We report here an effective course of immunotherapy consisting of the local injection and intra-venous administration of autologous tumor-cell-stimulated cytotoxic T lymphocytes in a patient with recurrent malignant melanoma. The patient was a 45-year-old woman. She had been diagnosed as having malignant melanoma in 1996 and under went radio-chemotherapy at our hospital. Seven years later, recurrences were recognized in bilateral nasal cavities. Following systematic chemotherapy, 23 local injections of cytotoxic T lymphocytes were performed. Mediastinal lymphonode metastasis was recognized in March, 2004, so 15 additional intravenous administrations of cytotoxic T lymphocytes were performed. At present, no obvious regrowth has been recognized. Immunotherapy using cytotoxic T lymphocytes may be a useful strategy for controlling recurrent malignant melanoma.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 109 (11), 781-784, 2006
一般社団法人 日本耳鼻咽喉科頭頸部外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679984171520
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- NII論文ID
- 10018561610
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- NII書誌ID
- AN00191551
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- ISSN
- 18830854
- 00306622
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- NDL書誌ID
- 8583944
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可