Intravascular large B-cell lymphoma associated with hypoalbuminemia and hypoxemia.

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  • YAGITA Masato
    Department of Clinical Immunology and Hematology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital
  • TABATA Rie
    Department of Clinical Immunology and Hematology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital
  • KONAKA Yoshiteru
    Department of Clinical Immunology and Hematology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital
  • OHNO Tatsuharu
    First Division, Department of Internal Medicine, Ohtsu Red Cross Hospital
  • TAKATSUKI Kiyoshi
    Department of Clinical Immunology and Hematology, Tazuke-Kofukai Medical Research Institute, Kitano Hospital

Bibliographic Information

Other Title
  • 著明な低酸素血症，低アルブミン血症を認めたｉｎｔｒａｖａｓｃｕｌａｒ　ｌａｒｇｅ　Ｂ‐ｃｅｌｌ　ｌｙｍｐｈｏｍａ
  • 症例 著明な低酸素血症,低アルブミン血症を認めたintravascular large B-cell lymphoma
  • ショウレイ チョメイ ナ テイサンソ ケッショウ テイアルブミン ケツショウ オ ミトメタ intravascular large B cell lymphoma

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Description

A 67-year-old man was referred to our hospital for treatment of hemophagocytic syndrome. Hypotension, hypoxemia, pleural effusion, severe anasarca, and splenomegaly were noticed at the time of admission. Laboratory findings showed anemia (7.7 g/dl), thrombocytopenia (4.5×104/μl), an increase of serum LDH (1,466 IU/L) and severe hypoalbuminemia (1.9 g/dl). Bone marrow aspiration revealed an increase of reticulum cells with active hemophagocytosis and the presence of immature lymphocytes (6.0%). Lymphoma was suspected, but effective chemotherapy could not be performed because of progressive hypoxemia and severe hypoalbuminemia, and the patient died of the disease 2 weeks after admission. Autopsy revealed large lymphoid cells packed within systemic vessels as well as invasion into organs such as the liver, lungs, and spleen. The postmortem diagnosis was intravascular large B-cell lymphoma. Hypoalbuminemia and hypoxemia appear to be important clinical features of intravascular large B-cell lymphoma.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 41 (11), 1189-1194, 2000

    The Japanese Society of Hematology

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