Triple secondary malignancy of gingiva, palate and esophagus after an allogeneic bone marrow transplantation for cutaneous T-cell lymphoma

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  • KOHARAZAWA Hideyuki
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • YAMAJI Satoshi
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • TAKASAKI Hirotaka
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • TAKABAYASHI Maki
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • FUJIMAKI Katsumichi
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • TAGUCHI Jun
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • KANAMORI Heiwa
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine
  • ISHIGATSUBO Yoshiaki
    Department Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine

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Other Title
  • 同種骨髄移植後，歯肉，口蓋，食道に三重複癌を発症した皮膚Ｔ細胞性リンパ腫
  • 症例 同種骨髄移植後,歯肉,口蓋,食道に三重複癌を発症した皮膚T細胞性リンパ腫
  • ショウレイ ドウシュ コツズイ イショク ゴ シニク コウガイ ショクドウ ニ 3 チョウフクガン オ ハッショウ シタ ヒフ Tサイボウセイ リンパ シュ

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Description

A 31-year-old man was diagnosed as having cutaneous T-cell lymphoma in January 1994. He received an allogeneic bone marrow transplantation (BMT) from an HLA-matched sibling donor in May 1995, because of refractoriness to chemotherapy. The patient had been treated with immunosuppressants including prednisolone and cyclosporin A for chronic graft-versus-host disease (GVHD) of the extensive type following acute GVHD. Five years after the BMT, he developed moderately differentiated squamous cell carcinoma (SCC) on the mandibular gingival mucosa and underwent surgical resection. Furthermore, 6 years after the BMT well differentiated SCC developed on his palate and was resected. Concurrently, he was diagnosed as having esophageal cancer (poorly differentiated SCC) and underwent a subtotal esophagotomy. One year later he had a recurrence of the esophageal cancer with dysphagia and was treated with radiation and chemotherapy. He remains free of triple cancer and lymphoma. It is suggested that total body irradiation, immunosuppressants, and chronic GVHD are associated with a risk of secondary malignancies following allogeneic BMT. These factors might have contributed to the onset of triple cancer in our patient.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 46 (7), 496-500, 2005

    The Japanese Society of Hematology

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