Cord blood transplantation for acute lymphoblastic leukemia in children: analysis at a single institution

DOI Web Site 13 References
  • KOBAYASHI Ryoji
    Department of Pediatrics, Sapporo Hokuyu Hospital Department of Pediatrics, Hokkaido University Hospital
  • SATO Tomonobu
    Department of Pediatrics, Sapporo Hokuyu Hospital Department of Pediatrics, Hokkaido University Hospital
  • NAKAJIMA Masahide
    Department of Pediatrics, Hokkaido University Hospital Department of Pediatrics, Asahikawa City Hospital
  • KANEDA Makoto
    Department of Pediatrics, Hokkaido University Hospital
  • IGUCHI Akihiro
    Department of Pediatrics, Hokkaido University Hospital Department of Pediatrics, Asahikawa Medical College Hospital
  • YOSHIDA Makoto
    Department of Pediatrics, Hokkaido University Hospital Department of Pediatrics, Asahikawa Medical College Hospital

Bibliographic Information

Other Title
  • 小児急性リンパ性白血病に対する臍帯血移植の検討
  • 臨床研究 小児急性リンパ性白血病に対する臍帯血移植の検討
  • リンショウ ケンキュウ ショウニ キュウセイ リンパセイ ハッケツビョウ ニ タイスル サイタイケツ イショク ノ ケントウ

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Description

We examined the result of cord blood transplantation (CBT) for acute lymphoblastic leukemia (ALL) in children. Fifty ALL patients underwent stem cell transplantation in our hospital. Among these, 23 patients received related bone marrow transplantation and peripheral blood stem cell transplantation (R-BMT/PBSCT), 17 patients received unrelated bone marrow transplantation (U-BMT), and 10 patients received unrelated cord blood transplantation (U-CBT). The 5-year overall survival rates after R-BMT/PBSCT, U-BMT and U-CBT were 64.6%, 32.3%, and 85.7%, respectively. Event-free survivals after 5 years were 59.6%, 14.7%, and 70.0%, respectively. The relapse rate in the U-CBT group was equal to that in the R-BMT/PBSCT group, and the transplant-related mortality of U-CBT was 0%. Our data show that U-CBT should be the first choice for patients with refractory or relapsed ALL who have no related HLA-matched donor.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 49 (12), 1593-1598, 2008

    The Japanese Society of Hematology

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