Management of pregnancy and delivery in patients with paroxysmal nocturnal hemoglobinuria

DOI Web Site PubMed

Bibliographic Information

Other Title
  • 発作性夜間ヘモグロビン尿症の妊娠・分娩管理
  • ホッサセイ ヤカン ヘモグロビン ニョウショウ ノ ニンシン ・ ブンベン カンリ

Search this article

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hemolytic anemia, which generally affects women of childbearing age. PNH hemolysis increases the risk of complications such as thrombosis during pregnancy and the postpartum period. Management of a pregnant woman with PNH remains a challenge due to the high incidence of thrombotic complications and the difficulty of differentiating a PNH crisis from the complications of pregnancy. PNH is associated with an increased rate of premature labor and fetal loss. Eculizumab, a C5 complement inhibitor, is a potential therapeutic option for such patients. This review presents the current strategies for the management of pregnant women with PNH, the cases experienced in our hospital, and the recently proposed remedy guide regarding the management of pregnancy in cases with PNH by the Pregnancy Working Group of The Japan PNH Interest group.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (7), 785-794, 2015

    The Japanese Society of Hematology

Keywords

Details 詳細情報について

Report a problem

Back to top