Reprogramming technology reveals genetic and functional diversity of subclones in myelodysplastic syndromes

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  • CHONABAYASHI Kazuhisa
    Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
  • YOSHIDA Yoshinori
    Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University
  • TAKAORI-KONDO Akifumi
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University

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Other Title
  • リプログラミング技術を用いた骨髄異形成症候群の腫瘍内遺伝的・機能的多様性の解明
  • 第77回日本血液学会学術集会 学会奨励賞受賞論文 リプログラミング技術を用いた骨髄異形成症候群の腫瘍内遺伝的・機能的多様性の解明
  • ダイ77カイ ニホン ケツエキ ガッカイ ガクジュツ シュウカイ ガッカイ ショウレイショウ ジュショウ ロンブン リプログラミング ギジュツ オ モチイタ コツズイイケイセイ ショウコウグン ノ シュヨウ ナイ イデンテキ ・ キノウテキ タヨウセイ ノ カイメイ

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Abstract

<p>Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell diseases characterized by inefficient hematopoiesis and poor prognosis. There are currently no useful tools for identifying new therapeutic targets of MDS mainly because of a lack of good disease models. Although massive parallel sequencing studies have revealed several MDS-specific genomic alterations that are different from those of de novo acute myeloid leukemia (AML), the relationships between the genetic architecture and pathophysiology in MDS remain poorly understood. We successfully generated multiple iPS cell lines (MDS-iPSC lines) from several patients with either MDS or secondary AML that progressed from MDS. We assessed the hematopoietic differentiation potential of the established MDS-iPSC lines and identified stage-specific maturation defects with graded severity. The MDS-iPSC lines could be a useful tool for elucidating the subclonal diversity, pathogenesis, and clonal evolution of MDS as well as for identifying new therapeutic compounds.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (7), 787-791, 2017

    The Japanese Society of Hematology

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