再生不良性貧血の重症度と予後の再検討

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タイトル別名
  • Reevaluation on the Severity and Prognostic Factors in Aplastic Anemia
  • サイセイ フリョウセイ ヒンケツ ノ ジュウショウド ト ヨゴ ノ サイケント

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抄録

The survival and its correlation with initial hematologic values of 169 patients with aplastic anemia were analysed in this study. According to survival terms, these patients could be divided into 3 groups: short-term (≤6 months), intermediate (6 months-5 years) and long-term (≥5 years) survivors. The correlation between the survival terms of the patients and their initial hematologic values were analysed and the usefulness of individual and integrative indices of initial hematologic values (reticulocytes≥1×104/cmm:1, neutrophils≥500/cmm:1, platelets≥3×104/cmm:0.5, and the percentage of hemopoietic cells in bone marrow≥30%:1.5) as prognostic indices was evaluated.<br>The integrative score of initial hematologic values was found to be a best prognostic indices. According to the integrative score, the severity of the disease was classified into 3 groups: severe (score 0∼2), moderate (score 2.5∼3.5) and mild (score 4).<br>As the patients with score 1 or less have extremely poor prognosis under the conventinal treatment, bone marrow transplantation will be recommended as an another therapeutic approach for these patients at this time, if they have a HLA compatible donor(s).

収録刊行物

  • 臨床血液

    臨床血液 19 (12), 1634-1640, 1978

    一般社団法人 日本血液学会

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