Cyclic Neutropeniaの1例及びその白血球遊走機能について

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タイトル別名
  • A Case of Cyclic Neutropenia with Special Reference to the Function of Neutrophil Mobilization
  • Cyclic Neutropenia ノ 1レイ オヨビ ソノ ハッケッキュウ

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This report concerns with cyclic neutropenia in a 7-year-3-month-old girl, having stomatitis, furunculosis, lymphadenitis and fever up to 39°C in the interval of approximately 3 weeks since the age of 2 weeks.<br>The peripheral blood picture after admission revealed that the neutropenia recurred every 19 days and the other formed elements of the blood, monocytes, lymphocytes, eosinophils, basophils and red blood cells, also showed periodic fluctuations. During the neutropenic phase, bone marrow was hypocellular with absence of mature neutrophils and increase in neutrophilic promyelocytes. During the neutrophilic phase, bone marrow was normocellular with increase in mature neutrophils, neutrophilic myelocytes and metamyelocytes and decrease in neutrophilic promyelocytes and myeloblasts. The serum protein electrophoresis showed hypergammaglobulinemia. Bone marrow granulocyte reserves to hydrocortisone and marginal granulocyte reserves to epinephrine were tested during both neutropenic and neutrophilic phases. It was concluded that bone marrow and marginal granulocyte pool sizes were generally small during the neutropenic phase. When no netrophils were present in the peripheral blood, local inflammatory response (skin window test) was hypocellular with mononuclear cell infiltrations 10 hours after abrasion. When netrophils were normal in number, abundant neutrophilic infiltration began 2 hours after the initiation of inflammation, and neutrophilic infiltration was gradually replaced by mononuclear cell infiltration beginning after 5 hours.

収録刊行物

  • 臨床血液

    臨床血液 17 (12), 1309-1319, 1976

    一般社団法人 日本血液学会

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