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Acute monoblastic leukemia with MLL/AF9 rearrangement which developed 18 months after myeloid sarcoma onset
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- SATO Yuya
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- NAKAZAWA Atsuko
- Department of Pathology, National Center for Child Health and Development
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- KUROSAWA Hidemitsu
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- FUKUSHIMA Keitaro
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- OKUYA Mayuko
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- HAGISAWA Susumu
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- SUGITA Kenichi
- Department of Pediatrics, Dokkyo Medical University School of Medicine
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- ARISAKA Osamu
- Department of Pediatrics, Dokkyo Medical University School of Medicine
Bibliographic Information
- Other Title
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- Myeloid sarcoma発症18か月後にMLL/AF9陽性急性単球性白血病と診断した男児例
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Description
We describe a 36-month-old boy with acute monoblastic leukemia (AMoL M5a) and mixed-lineage leukemia (MLL)-AF9 rearrangement. At 18 months of age, he presented with swelling on the back of his hand that was considered to be an inflammatory change, but no hematological abnormalities were found. However, blasts with MLL-AF9 rearrangement were detected in biopsied tissue taken at the time and in peripheral blood samples taken 18 months later. These findings indicate that myeloid sarcoma with MLL-AF9 rearrangement may ultimately, though slowly, progress to AMoL.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 54 (12), 2167-2170, 2013
The Japanese Society of Hematology