Blind Loop SyndromeにみられたVitamin B12 malabsorptionの発生機転について（続報）

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タイトル別名
  • Vitamin B12 Malabsorption in the Patients with Blind Loop Syndrome, a Continued Report
  • Blind Loop SyndromeにみられたVitamin B12 malabsorptionの発生機転について-続-
  • Blind Loop Syndrome ニ ミラレタ Vitamin B12

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Vitamin B12 (V. B12) malabsorption was observed in a patient with a blind loop in addition to our previous report. This malabsorption was not improved during the administration of tetracycline (TC), unlike the malabsorption previously experienced in four patients with blind loop syndrome. A large number of E. coli resistant to TC was found in the stool of the patient. The administration of Kanamycin effective to E. coli together with TC was followed by improvement of V. B12 malabsorption and disappearance of the E. coli. This finding strongly suggested that the microorganisms resident in the loop were important in the pathogenesis of the V. B12 malabsorption.<br>A serial study of the patient was performed regarding V. B12 absorption test, qualitative and quantitative analysis of fecal bacteria and in vitro measurement of the bacterial uptake of V. B12. The relationship between the rate of V. B12 absorption and the nature of flora was not apparent.<br>It was surprising that the rates of the V. B12 absorption tested one year after the cessation of antibiotics were still higher than those before Kanamycin. This phenomenon may suggest some important factors in V. B12 malabsorption other than the bacterial uptake of V. B12.

収録刊行物

  • 臨床血液

    臨床血液 18 (11), 1312-1317, 1977

    一般社団法人 日本血液学会

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