抗甲状腺剤による顆粒球減少症

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書誌事項

タイトル別名
  • Granulocytopenia Associated with Anti-thyroid Drugs
  • コウ コウジョウセンザイ ニヨル カリュウキュウ ゲンショウショウ

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説明

The incidence of granulocytopenia in association with anti-thyroid drugs has been studied. Of 78 patients treated with methimazole for the past six years, 7 cases developed neutropenia of less than 1,000/mm3. Decrease in neutrophil count more than 2,000/mm3 comparing to the values before the therapy was noted in 20.5% of the cases during the administration of the drug. Though most of the episodes of neutropenia were transient and reversible, one case developed classical symptoms of agranulocytosis.<br>Occurrence of neutropenia induced by methimazole is related to the duration of the therapy and seems to be dose-dependent. Therefore, frequent routine blood cell counts may be necessary for the early detection of leukopenia and prevention of agranulocytosis during anti-thyroid medication.

収録刊行物

  • 臨床血液

    臨床血液 17 (1), 82-87, 1976

    一般社団法人 日本血液学会

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