Epileptic encephalopathy associated with human herpes virus 6 (HHV-6) encephalitis after the second cord blood transplantation in a patient with pediatric acute lymphoblastic leukemia

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  • 臍帯血再移植後のHHV-6脳炎発症からてんかん性脳症を続発した小児急性リンパ性白血病
  • 症例報告 臍帯血再移植後のHHV-6脳炎発症からてんかん性脳症を続発した小児急性リンパ性白血病
  • ショウレイ ホウコク サイタイケツ サイイショク ゴ ノ HHV-6 ノウエン ハッショウ カラ テ ンカンショウ ノウショウ オ ゾクハツ シタ ショウニ キュウセイ リンパセイ ハッケツビョウ

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Abstract

The incidence of HHV-6 encephalitis during hematopoietic stem cell transplantation (HSCT) in children is thought to be less than that in adults and risk factors, prognosis and complications are virtually unknown. Herein, we report a pediatric case developing epileptic encephalopathy following HHV-6 encephalitis after a second cord blood transplantation (CBT). A 7-year-old boy with relapsed B-precursor acute lymphoblastic leukemia in second remission underwent CBT. However, he received a second CBT due to graft failure. On day 25 after the second CBT, he developed short-term memory defects and seizures. He was diagnosed with HHV-6 encephalitis because HHV-6 DNA was detected in his blood and cerebrospinal fluid and abnormal hippocampal signals were seen on cranial magnetic resonance imaging (MRI). After treatment with foscarnet, HHV-6 DNA levels and MRI findings improved; however, he developed epileptic encephalopathy five months after the onset of encephalitis. There are very few reports on pediatric epileptic encephalopathy associated with HHV-6 encephalitis after HSCT. Detailed studies are needed to analyze risk factors, prognosis, and complications.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 55 (12), 2418-2422, 2014

    The Japanese Society of Hematology

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