Lymphoplasmacytic lymphoma accompanied by transformed diffuse large B-cell lymphoma with the MYD88<sup>L265P</sup> mutation
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- KIDA Toru
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- TANIMURA Akira
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- ONO Akihiro
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- MATSUI Takahiro
- Department of Pathology, Osaka University Graduate School of Medicine
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- HONMA Keiichiro
- Department of Pathology, Osaka University Graduate School of Medicine
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- FUJITA Jiro
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- MAEDA Tetsuo
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- SHIBAYAMA Hirohiko
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- ORITANI Kenji
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
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- MORII Eiichi
- Department of Pathology, Osaka University Graduate School of Medicine
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- KANAKURA Yuzuru
- Department of Hematology and Oncology, Osaka University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 形質転換によりMYD88<sup>L265P</sup>変異を有するびまん性大細胞型B細胞性リンパ腫を同時に認めたリンパ形質細胞性リンパ腫
- 症例報告 第104回近畿血液学地方会 会長推薦演題 形質転換によりMYD88[L]²⁶⁵[P]変異を有するびまん性大細胞型B細胞性リンパ腫を同時に認めたリンパ形質細胞性リンパ腫
- ショウレイ ホウコク ダイ104カイ キンキ ケツエキガク チホウカイ カイチョウ スイセン エンダイ ケイシツ テンカン ニ ヨリ MYD88[L]² ⁶ ⁵[P]ヘンイ オ ユウスル ビマンセイ ダイ サイボウガタ B サイボウセイ リンパシュ オ ドウジ ニ ミトメタ リンパ ケイシツ サイボウセイ リンパシュ
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Description
<p>The gene mutation occurring with transformation in lymphoplasmacytic lymphoma (LPL) /Waldenström macroglobulinemia (WM) has not been fully elucidated. Herein, we report a 61-year-old man with LPL/WM. In this case, the MYD88 gene mutation appeared with transformation to diffuse large B-cell lymphoma (DLBCL). Bone marrow biopsy revealed the involvement of CD20 positive small plasmacytoid lymphocytes, indicating LPL/WM. However, the samples taken from both the cervical lymph node and the pleural effusion provided a pathological diagnosis of DLBCL. All samples showed the same patterns of surface antigen expressions and immunoglobulin gene rearrangements. Therefore, these lymphomas had identical clonality and were regarded as transformation from LPL/WM to DLBCL. The MYD88L265P mutation has recently been identified in most LPL/WM cases. The gene analysis in this case demonstrated that the MYD88L265P mutation was detectable in only the pleural effusion sample (DLBCL cells), not in the lymphoma cells of the bone marrow (LPL/WM cells). Thus, it was concluded that LPL/WM had transformed into DLBCL with the MYD88L265P mutation in this patient.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 58 (2), 155-160, 2017
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390282680014206592
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- NII Article ID
- 130005450487
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 028018103
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- PubMed
- 28321094
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed