Effect of Ciprofloxacin on Contractile Responses of Canine Airway Smooth Muscle
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- TAGAYA Etsuko
- First Department of Medicine, Tokyo Women's Medical College
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- TAMAOKI Jun
- First Department of Medicine, Tokyo Women's Medical College
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- TAKEMURA Hisashi
- First Department of Medicine, Tokyo Women's Medical College
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- CHIYOTANI Atsushi
- First Department of Medicine, Tokyo Women's Medical College
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- KONNO Kimio
- First Department of Medicine, Tokyo Women's Medical College
Bibliographic Information
- Other Title
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- イヌ摘出気道平滑筋の収縮に対するシプロフロキサシンの効果
- イヌ テキシュツ キドウ ヘイカツキン ノ シュウシュク ニ タイスル シプロ
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Abstract
To elucidate whether the new quinolone ciprofloxacin affects cholinergic neuro-effector transmission in the airway, we studied canine isolated bronchial segments under isometric conditions in vitro. Intrapulmonary lobar or segmental bronchi were suspended in the organ chambers filled with Krebs-Henseleit solution, and the isometric tension was continuously recorded by a force-displacement transducer.Addition of ciprofloxacin (2 × 10-3 M) attenuated the contractile responses to electrical field stimulation (EFS), so that the stimulus frequency required to produce a half-maximal contraction (ES50) increased from 1.2 ± 0.2 to 1.5 ± 0.2 Hz (p<0.05), whereas it was without effect on those to exogenously administered acetylcholine.The decrease in the EFS-induced contraction produced by ciprofloxacin was concentration-dependent and was not influenced by propranolol or tetraethylammonium, but partially inhibited by ouabain.These results suggest that ciprofloxacin may inhibit cholinergic neuro-effector transmission in the airway smooth muscle by inhibiting the exocytotic release of acetylcholine, probably involving the stimulation of Na+-K+-ATPase and concomitant repolarization/hyperpolarization of cholinergic nerve terminals.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 69 (4), 404-407, 1995
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680021447680
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- NII Article ID
- 130004330338
- 10008725902
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 3620316
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- PubMed
- 7751748
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed