Inhibition of the Infectivity of Influenza Virus by Black Tea Extract

DOI PubMed 2 Citations Open Access
  • NAKAYAMA Mikio
    Department of Virology, National Institute of Health Department of Microbiology and Immunology, Showa University School of Medicine
  • TODA Masako
    Department of Microbiology and Immunology, Showa University School of Medicine
  • OKUBO Sachie
    Department of Microbiology and Immunology, Showa University School of Medicine
  • HARA Yukihiko
    Food Research Laboratories, Mitsui Norin Co.
  • SHIMAMURA Tadakatsu
    Department of Microbiology and Immunology, Showa University School of Medicine

Bibliographic Information

Other Title
  • 紅茶エキスによるインフルエンザウイルス感染性の阻止
  • <I>in vivo</I>における検討

Description

We determined whether black tea extract inhibits the infectivity of influenza virus to mice. When mice were inoculated intranasally with 105.3 PFU influenza viruses (101.3 LD50), their body weight decreased and all died within 10 days. Whereas, when mice were inoculated i.n. with the mixture of influenza viruses and 2%(w/w) black tea extract, 5 min after mixing, all mice showed normal bodyweight increase and survived. Neutralizing antibody to influenza virus was not detected in nine of 10 survived mice.<BR>The results indicate that black tea extract at beverage concentration (2% w/w) inhibits almost completely the infectivity of influenza virus to mice and that in vivo reversion of the tea-inactivated influenza virus does not occur.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 68 (7), 824-829, 1994

    The Japanese Association for Infectious Diseases

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Keywords

Details 詳細情報について

  • CRID
    1390282680022438400
  • NII Article ID
    130004330257
  • DOI
    10.11150/kansenshogakuzasshi1970.68.824
  • COI
    1:STN:280:ByuA2srpsFQ%3D
  • ISSN
    1884569X
    03875911
    http://id.crossref.org/issn/03875911
  • PubMed
    8089547
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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