Evaluation of HIV-infected Patients Suspected as Having HIV-associated Neurocognitive Disorders
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- MORIOKA Hiroshi
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- KISHIDA Shuji
- Department of Neurology, Hatsuishi Hospital
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- IMAMURA Akifumi
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- SEKIYA Noritaka
- Department of Clinical Laboratory, Tokyo Metropolitan Komagome Hospital
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- YANAGISAWA Naoki
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- SUGANUMA Akihiko
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- AJISAWA Atsushi
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
Bibliographic Information
- Other Title
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- HIV 関連神経認知障害が疑われたHIV 感染者の検討
- HIV カンレン シンケイ ニンチ ショウガイ ガ ウタガワレタ HIV カンセンシャ ノ ケントウ
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Abstract
Background:HIV-associated neurocognitive disorders (HAND) have emerged as a problem among HIV-infected individuals in the era of antiretroviral therapy. However, there are insufficient data on HAND regarding its prevalence and clinical features in Japan. Methods:A test battery composed of eight neuropsycological tests proposed by the Ministry of Health,Labour and Welfare (MHLW test battery) was applied to assess 30 subjects at Tokyo Metropolitan Komagome Hospital. Among them, 5 subjects were excluded due to central nervous system complications. The background of each patient along with the results of head magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and neuropsychological tests were compared to each HAND category. In addition, the clinical utility of a combination of neuropsychological tests as an abbreviated test battery of HAND was evaluated. Results:A total of 19 (76%) subjects were diagnosed as having a HAND. Among them, HIV-associated dementia, mild neurocognitive disorders and asymptomatic neurocognitive disorders were diagnosed in 7, 8,and 4 subjects, respectively. Neither the patientʼs background nor the results of the head MRI and CSF analysis showed relevance to disease severity. The conventional International HIV Dementia Scale with the Digit Symbol Substitute Test was capable of detecting 94.7%cases of HAND. Conclusions:Most HIV-infected subjects clinically suspected as having neurocognitive disorders were diagnosed as having a HAND. Neuropsychological tests of the MHLW test battery were in some part useful to diagnose HAND. However, more precise neuropsychological tests are warranted to screen and diagnose HAND, based on the current criteria.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 88 (2), 141-148, 2014
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390282680027790336
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- NII Article ID
- 130005957344
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 025439911
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed