Double-Blind Trial of SF-837 in the Treatment of Respiratory Infections

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  • MASHIMO Keimei
    The 2nd Department of Internal Medicine, Hokkaido University, School of Medicine
  • KATO Yasumichi
    The 2nd Department of Internal Medicine, Hokkaido University, School of Medicine
  • MATSUMOTO Keizo
    The 1st Department of Internal Medicine, Tohoku University, School of Medicine
  • KINOSHITA Yasutami
    The 2nd Department of Internal Medicine, Niigata University, School of Medicine
  • YAMASAKU Fusanosuke
    The 2nd Department of Internal Medicine, Niigata University, School of Medicine
  • IKEMOTO Hideo
    Department of Internal Medicine, Juntendo University, School of Medicine
  • WATANABE Ikko
    Department of Internal Medicine, Juntendo University, School of Medicine
  • UEDA Yasushi
    Department of Internal Medicine, The Jikei University, School of Medicine
  • SAITO Atsushi
    Department of Internal Medicine, The Jikei University, School of Medicine
  • KOBAYASHI Chizuko
    Department of Internal Medicine, The Jikei University, School of Medicine
  • GOMI Jiro
    Department of Internal Medicine, Keio University, School of Medicine
  • AOYAGI Teruo
    Department of Internal Medicine, Keio University, School of Medicine
  • YAMADA Yoshihiro
    Department of Internal Medicine, Keio University, School of Medicine
  • KAWAKAMI Yasuo
    The 1st Department of Internal Medicine, Showa University, School of Medicine
  • NOGUCHI Hideo
    The 1st Department of Internal Medicine, Showa University, School of Medicine
  • NAKAGAWA Keiichi
    Department of Internal Medicine, Tokyo Kyosai Hospital
  • KABE Junzaburo
    Department of Internal Medicine, Tokyo Kyosai Hospital
  • ONUKI Toshie
    Department of Internal Medicine, Saiseikai Chuo Hospital
  • FUKAYA Kazufuto
    The Department of Internal Medicine, The Institute of Medical Science, The University of Tokyo
  • KATSU Masataka
    Department of Internal Medicine, Kawasaki City Hospital
  • FUJIMORI Ippei
    Department of Internal Medicine, Kawasaki City Hospital
  • SHIMADA Sachu
    Department of Internal Medicine, Kawasaki City Hospital
  • HIGASHI Fuyuhiko
    Department of Internal Medicine, Kawasaki City Hospital
  • Fujii Toshihiro
    Department of Internal Medicine, Kawasaki City Hospital
  • FUKUSHIMA Koukichi
    The 1st Department of Internal Medicine, Yokohama City University, Medical School
  • ITO Akira
    The 1st Department of Internal Medicine, Yokohama City University, Medical School
  • YAMAOKA Saburo
    Department of Internal Medicine, Yokohama Keiyu Hospital
  • YOKOYAMA Tsuyoshi
    Department of Internal Medicine, Yokohama Keiyu Hospital
  • YAMADA Ryuichiro
    Department of Internal Medicine, Tachikawa Kyosaikumiai Hospital
  • ISHIO Norihisa
    Department of Internal Medicine, Tachikawa Kyosaikumiai Hospital

Bibliographic Information

Other Title
  • 呼吸器感染症に対するSF-837の二重盲検試験
  • コキュウキ カンセンショウ ニ タイスル SF-837 ノ ニジュウ モウケンシケン

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Description

SF-837 is a new macrolide antibiotic isolated from the culture broth of Streptomyces mycarofaciens nov. sp.<BR>Results of the fundamental studies reported so far indicate that its antimicrobial antivity, absorption, distribution and excretion are quite similar to those of other macrolides.<BR>This paper describes the clinical results of comparative double-blind studies on SF-837 and kitasamycin in the treatment of respiratory infections such as acute tonsillitis, acute bronchitis and bacterial pneumonia.<BR>The satisfactory results were obtained in 61 paptients of 73 in the SF-837 group (83.6%) and in 62 patients of 77 in the kitasamycin group (80.5%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. (p<0.05;χ2=0.356)<BR>Generally, the most frequent side effect of macrolide antibiotics is gastrointestinal disturbance, the patients, therefore, were observed with a special attention to this point.<BR>As a result, gastrointestinal disturbances were observed in 6 out of 77 cases in the kitasamycin group and only one out of 73 cases in the SF-837 group.<BR>From the above results, SF-837 can be considered to be an effective antibiotic comparative to kitasamycin.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 46 (9), 332-341, 1972

    The Japanese Association for Infectious Diseases

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