A STUDY OF THE CLINICAL EFFECT OF ESTRADIOL TRANSDERMAL THERAPEUTIC SYSTEM ALONE ON POLLAKISURIA AND URINARY INCONTINENCE IN POSTMENOPAUSAL WOMAN

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  • 閉経後女性の頻尿・尿失禁に対するエストロゲン補充療法の臨床的検討
  • エストロゲン貼付剤単剤での検討

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(Purpose) Our purpose of this study was to evaluate the effect of a transdermal estradiol delivery system in postmenopausal women with confirmed pollakisuria and urinary incontinence.<br>(Patients and Methods) We investigated 10 postmenopausal women, age 54-83 years, with pollakisuria and urinary incontinence but did not show distinct urological and/or neurological abnormalities. In this study, estradiol transdermal therapeutic system (Estraderm TTS<sup>®</sup> 2mg) alone were administrated for total of 8-week and this is observatinal, not randomized, blinded or controlled. A clinical evaluation were performed two times at before and after administration.<br>(Results) In seven eligible cases, the severity of urinary incontinence was graded down in almost of them and the therapeutic effect on urinary incontinence was evaluated as “very effective” in 3 cases, “improved” in 2, “slightly improved” in 1 and “no change” in 1, respectively. In three eligible cases, the severity of pollakisuria was no change in all of them.<br>(Conclusion) Thus, the estrogen supplement therapy was considered effective for postmenopausal urinary incontinence.

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