Inhibition of δ-Aminolevulinic Acid Dehydratase by Styrene and Styrene Oxide

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  • MORI Koji
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • FUJISHIRO Kazuya
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • INOUE Naohide
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

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Other Title
  • スチレンおよびスチレンオキシドによるδ-アミノレブリン酸脱水素酵素の阻害

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Description

Effects of styrene and styrene oxide on δ-aminolevulinic acid dehydratase in rats were investigated, in vivo and in vitro. In the in vivo study, rats were exposed to styrene or styrene oxide intraperitoneally for seven days. δ-Aminolevulinic acid dehydratase in the erythrocyte was inhibited by both styrene and styrene oxide. The inhibition by styrene oxide had a clear dose-response relationship, but that by styrene did not. In the liver, however, these substances did not inhibit δ-aminolevulinic acid dehydratase. In the in vitro study, styrene oxide inhibited δ-aminolevulinic acid dehydratase both in the erythrocyte and in the liver, but styrene failed to inhibit it. These results suggest that styrene is metabolized to styrene oxide, and this metabolite inhibits δ-aminolevulinic acid dehydratase. It is also thought that the discrepancy of inhibition between the erythrocyte and the liver is due to a difference of distribution and metabolism of the substances.

Journal

  • Journal of UOEH

    Journal of UOEH 10 (3), 269-275, 1988

    University of Occupational and Environmental Health, Japan

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