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- Vanhoutte Paul M.
- Department of Pharmacology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
書誌事項
- タイトル別名
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- Endothelial Dysfunction The First Step Toward Coronary Arteriosclerosis
- The First Step Toward Coronary Arteriosclerosis
- 公開日
- 2009
- DOI
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- 10.1253/circj.cj-08-1169
- 公開者
- 一般社団法人 日本循環器学会
この論文をさがす
説明
The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing nitric oxide (NO). The endothelial cells also can evoke hyperpolarization of the vascular smooth muscle cells (endothelium-dependent hyperpolarizations, endothelium-derived hyperpolarizing factors-mediated responses). Endothelium-dependent relaxations involve both pertussis toxin-sensitive Gi and pertussis toxin-insensitive Gq coupling proteins. The endothelial release of NO is reduced in diabetes and hypertension. Arteries covered with regenerated endothelium lose the pertussis-toxin sensitive pathway for NO-release. This dysfunction favors vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. Endothelial cells also release endothelium-derived contracting factors (EDCF). Most endothelium-dependent contractions are mediated by vasoconstrictor prostanoids (endoperoxides and prostacyclin), which activate thromboxane-prostanoid (TP)-receptors of the underlying vascular smooth muscle cells. EDCF-mediated responses are augmented by aging, hypertension and diabetes. Thus, endothelial dysfunction is the first step toward coronary arteriosclerosis. (Circ J 2009; 73: 595 - 601)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 73 (4), 595-601, 2009
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680081753600
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- NII論文ID
- 10025928764
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
- https://id.crossref.org/issn/13469843
- http://id.crossref.org/issn/13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
