Impact on Clinical Outcomes of Periodic Leg Movements During Sleep in Hospitalized Patients Following Acute Decompensated Heart Failure

DOI Web Site Web Site PubMed 被引用文献5件 参考文献32件
  • Yatsu Shoichiro
    Department of Cardiovascular Medicine, Juntendo University School of Medicine
  • Kasai Takatoshi
    Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Suda Shoko
    Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Matsumoto Hiroki
    Department of Cardiovascular Medicine, Juntendo University School of Medicine Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Shiroshita Nanako
    Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Kato Mitsue
    Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Kawana Fusae
    Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Murata Azusa
    Department of Cardiovascular Medicine, Juntendo University School of Medicine
  • Kato Takao
    Department of Cardiovascular Medicine, Juntendo University School of Medicine
  • Hiki Masaru
    Department of Cardiovascular Medicine, Juntendo University School of Medicine
  • Daida Hiroyuki
    Department of Cardiovascular Medicine, Juntendo University School of Medicine

この論文をさがす

説明

<p>Background:Periodic leg movements during sleep (PLM) are characterized by regularly recurring movement of the legs during sleep. Although PLM is common and a predictor of death in patients with chronic heart failure, the clinical significance of PLM in hospitalized patients with a reduced left ventricular ejection fraction (LVEF) following acute decompensated heart failure (ADHF) remains unknown.</p><p>Methods and Results:After initial improvement of acute signs and symptoms of ADHF, 94 consecutive patients with reduced LVEF who underwent polysomnography were enrolled. They were divided into 2 groups based on the presence or absence of severe PLM defined as PLM index ≥30. The risks for clinical events, composite of all-cause death and rehospitalization, were assessed using a stepwise multivariable Cox proportional model including variables showing P<0.10 in univariate analyses. Severe PLM was observed in 21 patients (22%). At a median follow-up of 5.2 months, 30 patients experienced clinical events (32%). In the multivariable analysis, the presence of severe PLM was significantly associated with increasing clinical events (hazard ratio, 2.16; 95% confidence interval, 1.03–4.54; P=0.042) independent of hemoglobin level and the severity of sleep-disordered breathing.</p><p>Conclusions:In hospitalized patients with systolic dysfunction following ADHF, severe PLM was prevalent and significantly associated with increased risk of death and/or rehospitalization.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (4), 495-500, 2017

    一般社団法人 日本循環器学会

被引用文献 (5)*注記

もっと見る

参考文献 (32)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ