Endothelial Dysfunction via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1: Close Relationships With Oxidative Stress

DOI Web Site PubMed 被引用文献8件 参考文献54件
  • Sakurai Kanako
    Department of Bioscience, National Cardiovascular Center Research Institute
  • Sawamura Tatsuya
    Department of Bioscience, National Cardiovascular Center Research Institute

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  • Stress and Vascular Responses: Endothelial Dysfunction via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1: Close Relationships With Oxidative Stress

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Endothelial dysfunction is associated with pathological vascular conditions including atherosclerosis, hypertension, and diabetes. The oxidatively modified form of low-density lipoprotein (LDL) is recognized as a major cause of endothelial dysfunction in atherogenesis. As the receptor for oxidized LDL in endothelial cells, we have identified the lectin-like oxidized LDL receptor-1 (LOX-1). LOX-1 is up-regulated by products of oxidative stresses and the molecules that induce oxidative stresses. Activation of LOX-1 induces the generation of reactive oxygen species and decreases NO released from endothelial cells. LOX-1 activation further induces the expression of endothelin-1, AT1 receptor, and cell adhesion molecules. Together with these properties, LOX-1 works as an adhesion molecule for activated platelets and neutrophils. Thus, LOX-1, within the close relationships between oxidative stress generation and response, enhances functional changes in endothelial cells that are relevant to the disturbed vascular homeostasis under pathological settings.<br>

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