Efficacy of Antihistamines for Histamine-induced Reactions in Lesional Skin of Patients with Atopic Dermatitis : A Comparative Study with Hydrochloride - Fexofenadine, -Olopatadine and -Cetirizine

DOI
  • Kato Mayumi
    Department of Dermatology, Graduate School of Medicine, Kyoto University
  • Hosogi Miwa
    Department of Dermatology, Graduate School of Medicine, Kyoto University
  • Miyachi Yoshiki
    Department of Dermatology, Graduate School of Medicine, Kyoto University
  • Ikoma Akihiko
    Department of Dermatology, Graduate School of Medicine, Kyoto University

Bibliographic Information

Other Title
  • アトピー性皮膚炎患者におけるヒスタミン誘発反応に対する抗ヒスタミン薬の有効性に関する検討 ―塩酸フェキソフェナジン，塩酸オロパタジンおよび塩酸セチリジンの比較検討―

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Description

Histamine induces intense itch in lesional skin, which is sensitized for itch, of patients with atopic dermatitis. We investigated the efficacy of a regular dose of antihistamines for this intense itch. Histamine iontophoresis was perfomed before and three hours after application of hydrochloride-fexofenadine, -olopatadine, -cetirizine, or placebo in ten patients with atopic dermatitis. The suppression of histamine-induced reactions was compared among the applied drugs. The result was that all the antihistamines almost completely suppressed histamine-induced reactions. Taking into account that patients with atopic dermatitis actually complain of itch even three hours after application of antihistamines, this result suggests that non-histaminergic mechanisms also play an important role in pruritus of atopic dermatitis.

Journal

  • Hifu no kagaku

    Hifu no kagaku 5 (4), 279-283, 2006

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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