A Case of the Immediate Allergy to Erythritol

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  • エリスリトールによる即時型アレルギーの1例

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A 17-year-old female with pollinosis developed wheals over her entire body and dyspnea after eating chocolate, lemon juice, and home-made sweet potato cake made of bean-curd refuse, sweet potatoes and low calorie granular sweetener. She had a past history of similar symptoms after ingesting grape-flavored jelly and pear juice, and thought she had a fruit allergy. Skin prick/scratch tests were positive for low calorie granular sweetener, the grape-flavored jelly and pear juice. The common ingredient in these three products was erythritol, and the prick test with erythritol was positive at concentrations of more than 10mg/ml. At the oral challenge test, 500mg of erythritol induced wheals, leading us to diagnose an immediate allergy to erythritol complicated by oral allergy syndrome, as suggested by the results of the skin and challenge tests. The two products that caused the symptoms contained approximately 5g of erythritol, which is enough to induce anaphylactic shock. Erythritol is widely used as a zero-calorie sweetener, and occurs naturally at extremely low levels as opposed to its concentration when used as an artificial sweetener. Although erythritol allergy is rare, this condition may be masked by a fruit allergy. Consequently, we should increase our awareness of this potential diagnosis.Skin Research, 16: 133-138, 2017

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  • Hifu no kagaku

    Hifu no kagaku 16 (2), 133-138, 2017

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

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