Experimental Study on a Novel Chemical Application Procedure for <i>in Vitro</i> Skin Corrosivity Testing Using the Vitrolife-Skin<sup>TM</sup> Human Skin Model

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During the last decade, ECVAM has supported formal validation studies on in vitro tests for predicting skin corrosivity, which included two of the in vitro tests employed human skin models, EPISKINTM and EpiDermTM. When skin models are used to evaluate skin irritancy and corrosivity, it is important that suitable chemical application procedures are utilized. We used several chemicals and evaluated their skin corrosivity using in vitro tests, evaluations using ECVAM experimental protocols and post-incubation methods that we have originally developed to predict skin irritancy, and compared the results. Vitrolife-Skin showed basic utility for corrosivity testing by both methods and it is possible to confidently predict skin corrosivity, provided that the appropriate chemical application procedures are used. In the future, human skin models will become very useful for purposes of predicting in vivo skin corrosivity of chemicals and for studying the mechanistic aspects of such corrosivity.

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