Hepatoprotective activity of Eclipta prostrata L[INN.] extract in ethanol induced rat hepatic injury
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- PRAMYOTHIN Pornpen
- Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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- TUNGKASEN Hatairuk
- Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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- POUNGSHOMPOO Somlak
- Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University
書誌事項
- タイトル別名
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- Hepatoprotective activity of <I>Eclipta prostrata</I> L<SUB>INN</SUB>. extract in ethanol induced rat hepatic injury
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This study was undertaken to investigate the hepatoprotective activity of Eclipta prostrata LINN. (EP) in ethanol induced rat hepatic injury. In the in vitro study, EP (0.1, 0.2, 0.3 mg/ml) increased % MTT reduction and decreased the release of transaminases (ALT and/or AST) in rat primary cultured hepatocytes being treated with ethanol. Hepatotoxic markers studied in rats included serum transaminases (ALT and AST), serum triglyceride (STG), hepatic triglyceride (HTG), TNF-α and IL-1β together with histopathological examination. Pretreatment of rats with EP at oral dose of 10, 20, 30 mg/kg and silymarin (a reference hepatoprotective agent) at 5 mg/kg 4 h before ethanol (5 g/kg, p.o.) decreased the ethanol induced levels of ALT and/or AST. The 30 mg/kg EP dose gave the best result similar to SL. Treatment of rats with EP (30 mg/kg/day) or SL (5 mg/kg/day) for 7 days after 21 days with ethanol (4 g/kg/day, p.o.) enhanced liver cell recovery by bringing the levels of ALT, AST and IL-1β back to normal. Histopathological observations confirmed the beneficial roles of EP and SL against ethanol induced liver injury in rats. Possible mechanism may involve their antioxidant activity.
収録刊行物
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 24 (5), 164-167, 2007
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詳細情報 詳細情報について
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- CRID
- 1390282680210611328
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- NII論文ID
- 130004495500
- 110006437773
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- NII書誌ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- NDL書誌ID
- 9263660
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可