オウゴンの加工調製法ならびに栽培年数が成分に与える影響と一酸化窒素産生抑制活性について

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  • Influence of Processing after Harvesting and Cultivation Year on the Components of Scutellariae Radix (<i>Scutellaria baicalensis</i> Georgi) and Inhibitory Effect of Their Constituents on Nitric Oxide Production
  • オウゴン ノ カコウ チョウセイホウ ナラビニ サイバイ ネンスウ ガ セイブン ニ アタエル エイキョウ ト イッサンカ チッソ サンセイ ヨクセイ カッセイ ニ ツイテ

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<p>This paper describes the influence of post-harvest processing and the cultivation year on the components of the root of Scutellaria baicalensis Georgi. The major flavonoid glycosides of Scutellariae Radix extract, baicalin and wogonoside were reduced by drying at high temperatures. The glycosides were also enzymatically hydrolyzed and C-glycoside was stable under any drying condition. Flavonoid glycosides were stored in the thin part of two-year-old roots and the bold part of one- and three-year-old roots, whereas aglycones were preserved in the bold part of two-year-old roots. However, in the freeze-dried samples unaffected by temperature and enzymatic activity, the glycosides were found in the bold roots and aglycones were found in the thin roots as expected. Furthermore, analysis of eight isolated compounds showed that wogonoside, wogonin and baicalein had potent inhibitory effects on NO production.</p>

収録刊行物

  • 生薬学雑誌

    生薬学雑誌 70 (1), 1-9, 2016

    一般社団法人 日本生薬学会

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