Genotypic frequency of dynamin 1 mutation in service dog breeding colonies in Japan

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  • 我が国の身体障害者補助犬の繁殖コロニーにおけるダイナミン 1遺伝子の突然変異頻度について
  • ワガクニ ノ シンタイ ショウガイシャ ホジョケン ノ ハンショク コロニー ニ オケル ダイナミン 1 イデンシ ノ トツゼン ヘンイ ヒンド ニ ツイテ

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Abstract

<p>In 2008, it has been reported that the syndrome of exercise-induced collapse in Labrador retrievers, the most common breed for service dog, was associated with a mutation in the dynamin 1 gene. To facilitate the service dog in a society, control of public health including zoonosis and management of genetic diseases which associated with potential as service dogs might be essential elements. In this study, genotypic frequency of dynamin 1 mutation was examined in service dog colonies in Japan. When DNA derived from 162 Labrador retrievers in breeding colonies of service dog were analyzed by restriction fragment length polymorphism for dynamin 1 gene mutation, percentages of wild type, heterozygous mutant and homozygous mutant were 66%, 30% and 4%, respectively. As intense exercises are not requested during their training and/or working in service dogs, homozygous mutation of dynamin 1 may not affect their potential as a service dog. When service dogs are made alterations in their role as career changed dogs, however, the genotype of dynamin 1 may influence their activities. Thus, knowing the degree of density and distribution of the gene mutations in breeding colony is expected to contribute to facilitate service dogs to a society. These results might contribute to make a plan for effective breeding in service dog colony. </p>

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