含硫アミノ酸のジクロルアセチル化

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タイトル別名
  • Dichloroacetylation of Sulfur-containing Amino Acids.
  • ガンリュウアミノサン ノ ジクロルアセチルカ

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抄録

Cancer inhibitors may be mentioned as one of the most urgently needed chemicals at present. It was found that a certain amino acid showed carcinogenic inhibition. In this report, the synthesis of sulfur-containing amino acids, especially of dichloroacetyl derivatives are described. Methionine, its oxidized substances and its esters, cysteine, cystine and its esters were selected as starting materials. Their acylations were made by (A) Schotetn-Baumann's method and (B) by Kameda's method. The results indicated that the sulfur-containing amino acids in general gave higher yield and higher purity of objective compounds in the B method than in the A method, while the synthesis was easier by use of the A Method in case of esters.

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