Biocatalyst for Asymmetric Synthesis-Chiralscreen-
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- Hayashi Motoko
- Life Science Development Center, CPI Company, Daicel Chemical Industries, Ltd.
Bibliographic Information
- Other Title
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- 不斉合成バイオ触媒―Chiralscreen―
- フセイ ゴウセイ バイオ ショクバイ Chiralscreen
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Abstract
Chiralscreen® is biocatalyst, i.e. enzyme for asymmetric synthesis. Chiralscreen® OH for chiral alcohols and Chiralscreen® NH for chiral amino acids and amines are available. It catalyzes the desired reaction in high regio/stereo selectivity under mild conditions without dangerous reagents. For example, chemical reduction requires hydride reagent or hydrogen, however, pseudo-hydride donor of reduction with Chiralscreen® is formate or glucose. The solvent is water, and the reactions proceeds under ambient pressure and room temperature. Therefore, special facilities and safety counterplans are not needed for the reactions. The solubility of substrate in the water is not essential for the reaction. We have an example that slightly soluble ketone (solubility in water is 0.05%) is reduced quantitatively in perfect selectivity. Chiralscreen® is produced using recombinant cell, however, endotoxin, DNA, and/or proteins derived from microbe are not detected in the product.
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 69 (5), 517-525, 2011
The Society of Synthetic Organic Chemistry, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282680289270400
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- NII Article ID
- 10028293378
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- NII Book ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3MXms1Kiurk%3D
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 11115596
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed