ON THE r<SUP>+</SUP> ANTIGEN SPECIFIC TO BACTERIAL STRAINS HAVING THE DRUG RESISTANCE TRANSFER FACTOR R

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  • 薬剤耐性伝達因子R因子をもつ菌に特異なr<SUP>+</SUP>抗原について
  • ヤクザイ タイセイ デンタツ インシ R インシ オ モツ キン ニ トクイ ナ r コウゲン ニ ツイテ

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Abstract

1. An antibody, specifically reacting with R+ strains, was demonstrated in an immune serum obtained by injecting a rabbit either with R+100-1 strain of E.coli or with R+ strain of Salmonella<BR>2. E. coli r+ antiserum and S r+ antiserum were absorbed with E.coli R+ strain and Salmonella R+ strain, alternately. Thc result indicated that r+ antigens of E.coli and Salmonella wonld have their specific antigenicities as well as common antigenicity.<BR>3. Bacterial suspensions of E.coli R+ and Salmonella R+ strain were treated with a blendor, and the whole was centrifuged.<BR>Then the supernatant was recentrifuged twice. first at 18, 000 r. p. m.and then at 38, 000 r.p.m. And r+ antigenicity was demonstrated in the fraction which was sedimented by the 38, 000 r p.m.centrifugation.<BR>4. The r+ antigenicity of the living cells or of its ultracentrifuged fraction was lost when it was heated at 100°C for 30 min., or treated with proteinases such as trypsin, ficin or bromelin.<BR>It is consequently assumed that the r+ antigen would have proteinic properties.

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