Psychoses and epilepsy, update and controversies

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  • Matsuura Masato
    Tasaki Hospital Professor Emeritus, Tokyo Medical and Dental University

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  • てんかんと精神病の双方向関係
  • テンカン ト セイシンビョウ ノ ソウホウコウ カンケイ

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Epilepsy is a risk factor for the development of psychoses, and psychoses could be a risk factor for the development of epilepsy. The continuous bell - curve shape distribution of time interval from onset of epilepsy (psychosis) to that of psychosis (epilepsy) indicates a shared underlying biological mechanism. Brain morphological studies showed widespread grey and white matter changes both in psychoses and epilepsy. Neurodevelopmental deficits may play a role in both psychoses and epilepsy. Recent molecular genetic findings suggest that the comorbidity of psychoses and epilepsy is a product of shared underlying biological mechanisms. A bidirectional relationship between epilepsy and psychoses have been proposed.

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