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- YOKOTA MASAYUKI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- TAKEDA UETO
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- ODAKI MASUZO
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- SASAKI HITOSHI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- NIIZATO TETSUTARO
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- KAWAOTO HARUO
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- WATANABE HIROSHI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- ITOH TAKASHI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- ISHIWATARI NOBUYOSHI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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- KOEDA TAKEMI
- Laboratory of Safety Evaluation, Central Research Laboratories, Meiji Seika Kaisha, Ltd.
Bibliographic Information
- Other Title
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- CHRONIC TOXICITY IN RATS
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Description
Miocamycin (MOM) is a derivative of midecamycin (MDM), a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens1, 2). Its chemical structure is shown in Fig. 1. It is reported that MOM has the most interesting antibacterial properties among the known macrolide antibiotics3, 4). It has been known that the maximum tolerable dosage level of MOM, non-crystalline solid, was 1, 000 mg/kg in male and female rats when it was orally administered once daily for 5 weeks at daily dosage levels of 1, 000, 2, 000 and 4, 000 mg/kg as previously reported5).<BR>The objective of this study was to examine toxicological effects in male and female rats after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at daily dosage levels of 62. 5, 125, 250, 500 and 1, 000mg/kg.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 37 (7), 1355-1375, 1984
Japan Antibiotics Research Association
