急性中耳炎ならびに急性扁桃炎に対する3, 4-dideoxykanamycin Bの二重盲検試験による薬効評価

DOI
  • 三辺 武右衛門
    Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
  • 村上 温子
    Debartment of Otorhinolaryngology. Kanto Teishin Hospital, Tokyo. Japan.
  • 粟田口 省吾
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • 斉藤 久樹
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • 鎌田 重輝
    Department of Otorhinolaryngology. Hirosaki University School of Medicine, Hirosaki. Japan.
  • 河本 和友
    Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
  • 堀 克孝
    Department of Otorhinolaryngology. Tohoku University School of Medicine. Sendai. Japan.
  • 河村 正三
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • 市川 銀一郎
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • 杉田 麟也
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo. Japan.
  • 山下 公一
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • 渋井 弘一
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • 小川 明
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
  • 小倉 脩二
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • 小林 康夫
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • 益子 三郎
    Department of Otorhinolaryngology, Japan Red Cross Medical Center, Tokyo. Japan.
  • 法水 正文
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
  • 坊野 馨二
    Department of Otorhinolaryngology, Tokyo Teishin Hospital, Tokyo, Japan.
  • 馬場 駿吉
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • 本堂 潤
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • 和田 健二
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • 波多野 努
    Department of Otorhinolaryngology, Nagoya City University Medieal School, Nagoya, Japan.
  • 関谷 忠雄
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • 大塚 基
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • 宮川 公文
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • 鈴木 茂
    Department of Otorhinolaryngology, Nagoya National Hospital, Nagoya, Japan.
  • 山本 馨
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • 杉山 正夫
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • 山崎 太朗
    Department of Otorhinolaryngology, Osaka CityUniversity Medical School, Osaka, Japan.
  • 広戸 幾一郎
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • 林田 邦彦
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • 山田 篤伸
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University Fukuoka, Japan.
  • 佐藤 喜一
    Department of Pathology, lnstitute for the Deaf, Tokyo Medical and Dental University, Tokyo, Japan.

書誌事項

タイトル別名
  • Double-Blind Trial of 3, 4-dideoxykanamycin B in the Treatment of Acute Supprative Otitis Media and Acute Tonsillitis

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抄録

3, 4-dideoxykanamycin B is a new semisynthetic aminoglycosidic antibiotic derivated from Kanamycin B. Results of the fundamental studies on this drug reported that antimicrobial activity against Pseudomonas aeruginosa is more excellent than the other aminoglycosidic antibiotics. This paper describes the clinical results of comparative double-blind test on 3, 4-dideoxykanamycin B (DKB) and Gentamicin sulfate (GM) in the treatment of acute supprative otitis media and acute tonsillitis.<BR>Satisfactory results were obtained in 48 patients of 65 in the DKB group (73.9%) and in 41 patients of 63 in the GM group (65.1%). Statistical analysis of the obtained results revealed that there was no significant difference between the two groups. Generally, the most noteworthy side effect of aminoglycosidic antibiotics is ototoxity. Therefore, the patients in this study were observed with special attention to this point. But no disturbance of inner ear was noted in the DKB group. From the above results, 3, 4-dideoxykanamycin B (DKB) can be an effective antibiotic comparative to Gentamicin.

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