The efficacy of Cepharanthin in the treatment of otitis media with effusion

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  • 滲出性中耳炎に対するビスコクラウリン型アルカロイド製剤 (セファランチン®) 有用性の検討
  • 臨床至適用量設定試験

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The efficacy of Cepharanthin in the treatment of otitis media with effusion was examined in children by means of a well designed clinical protocol. The objective symptoms, pure tone audiometry and a tympanogram were all monitored before and after a tympanostomy, an aspiration of the middle ear effusion and the subsequent administration of different doses of Cepharanthin.<BR>As a result of the above examinations, the global improvement rating was found tobe the highest in the group of patient receiving a 2mg/kg dose of Cepharanthin. This finding is thus considered to indicate the efficacy of Cepharanthin for the treatment of otitis media with effusion which isoften seen in children.

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