耳鼻咽喉科領域感染症に対するAzithromycinの基礎的ならびに臨床的検討

  • 馬場 駿吉
    Department of Otorhinolaryngology. Nagoya City University, Medical School
  • 宮本 直哉
    Department of Otorhinolaryngology. Nagoya City University, Medical School
  • 海野 徳二
    Department of Otorhinolaryngology, Asahikawa Medical School
  • 野中 聡
    Department of Otorhinolaryngology, Asahikawa Medical School
  • 金井 直樹
    Department of Otorhinolaryngology, Kitami Red Cross Hospital
  • 渡辺 昭仁
    Department of Otorhinolaryngology, Wakkanai City Hospital (Department of Otorhinolaryngology, Furano Kyokai Hospital)
  • 林 浩
    Department of Otorhinolaryngology, Wakkanai City Hospital (Department of Otorhinolaryngology, Furano Kyokai Hospital)
  • 上戸 敏彦
    Department of Otorhinolaryngology, Nikko Kinen Hospital
  • 市川 銀一郎
    Department of Otorhinolaryngology, School of Medicine, Juntendo University
  • 桜井 淳
    Department of Otorhinolaryngology, School of Medicine, Juntendo University
  • 山川 卓也
    Department of Otorhinolaryngology, School of Medicine, Juntendo University
  • 板橋 隆嗣
    Department of Otorhinolaryngology, Koto Hospital
  • 深本 克彦
    Department of Otorhinolaryngology, Juntendo Izunagaoka Hospital
  • 三宅 浩郷
    Department of Otorhinolaryngology, Tokai University, Tokyo Hospital
  • 佐藤 むつみ
    Department of Otorhinolaryngology, Tokai University, Tokyo Hospital
  • 高橋 秀明
    Department of Otorhinolaryngology, Tokai University, Tokyo Hospital
  • 緒方 哲郎
    Department of Otorhinolaryngology, Tokai University, Tokyo Hospital
  • 山崎 充代
    Department of Otorhinolaryngology, Tokai University, Tokyo Hospital
  • 坂井 眞
    Department of Otorhinolaryngology, School of Medicine, Tokai Univerisity
  • 新川 敦
    Department of Otorhinolaryngology, School of Medicine, Tokai Univerisity
  • 木村 栄成
    Department of Otorhinolaryngology, School of Medicine, Tokai Univerisity
  • 出井 教雄
    Department of Otorhinolaryngology, School of Medicine, Tokai Univerisity
  • 西村 忠郎
    Department of Otorhinolaryngology, Second Hospital of Fujita Health University
  • 徳田 寿一
    Department of Otorhinolaryngology, Second Hospital of Fujita Health University
  • 岡本 啓孝
    Department of Otorhinolaryngology, Second Hospital of Fujita Health University
  • 横田 明
    Department of Otorhinolaryngology, Nagoya City Higashi General Hospital
  • 加藤 薫
    Department of Otorhinolaryngology, Nagoya City Higashi General Hospital
  • 小林 武弘
    Department of Otorhinolaryngology, Kasugai City Hospital
  • 坂井 邦充
    Department of Otorhinolaryngology, Kasugai City Hospital
  • 柘植 勇人
    Department of Otorhinolaryngology, Toyohashi City Hospital
  • 森部 一穂
    Department of Otorhinolaryngology, Toyohashi City Hospital
  • 亀井 壮太郎
    Department of Otorhinolaryngology, Toyohashi City Hospital
  • 纐纈 正和
    Department of Otorhinolaryngology, Koseiren Showa Hospital
  • 北尾 俊二
    Department of Otorhinolaryngology, Koseiren Showa Hospital
  • 小島 憲
    Department of Otorhinolaryngology, Koseiren Showa Hospital
  • 高橋 真理子
    Department of Otorhinolaryngology, Koseiren Showa Hospital
  • 本庄 巖
    Department of Otorhinolaryngology, School of Medicine, Kyoto University (The Kansai Power Company Incorporated Hospital)
  • 藤田 明彦
    Department of Otorhinolaryngology, School of Medicine, Kyoto University (The Kansai Power Company Incorporated Hospital)
  • 倉田 響介
    Department of Otorhinolaryngology, School of Medicine, Kyoto University (The Kansai Power Company Incorporated Hospital)
  • 松永 亨
    Department of Otorhinolaryngology, Osaka University, Medical School
  • 久保 武
    Department of Otorhinolaryngology, Osaka University, Medical School
  • 肥塚 泉
    Department of Otorhinolaryngology, Osaka University, Medical School
  • 芦田 健太郎
    Department of Otorhinolaryngology, Kawanishi City Hospital
  • 村田 潤子
    Department of Otorhinolaryngology, Kawanishi City Hospital
  • 仙波 治
    Department of Otorhinolaryngology, Osaka Koseinenkin Hospital
  • 石田 稔
    Department of Otorhinolaryngology, Osaka Prefectural Hospital
  • 佐藤 信次
    Department of Otorhinolaryngology, Osaka Police Hospital
  • 原田 康夫
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 夜陣 紘治
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 鈴木 衛
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 平川 勝洋
    Department of Otorhinolaryngology, School of Medicine, Hiroshima University
  • 田頭 宣治
    Department of Otorhinolaryngology, Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital
  • 平田 したう
    Department of Otorhinolaryngology, Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital
  • 白根 誠
    Department of Otorhinolaryngology, Hiroshima Railway Hospital
  • 小林 優子
    Department of Otorhinolaryngology, Hiroshima Mitsubishi Hospital
  • 永澤 容
    Department of Otorhinolaryngology, Futami Central Hospital (Miyoshi Public Central Hospital)
  • 大山 勝
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 古田 茂
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 松崎 勉
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 清田 隆二
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 大野 文夫
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 出口 浩二
    Department of Otorhinolaryngology, School of Medicine, Kagoshima Unversity
  • 矢野 博美
    Department of Otorhinolaryngology, Saiseikai Sendai Hospital
  • 原口 兼明
    Department of Otorhinolaryngology, Kagoshima Seikyo Hospital
  • 柴 孝也
    Second Department of Internal Medicine, School of Medicine, The Jikei University
  • 齋藤 厚
    The First Department of Internal Medicine, School of Medicine, University of the Ryukyus
  • 島田 馨
    Department of Infections Disease, Institute of Medical Science, University of Tokyo (Tokyo Senbai Hospital)

書誌事項

タイトル別名
  • Pharmacoeinetic and clinical studies of Azithromycin on otorhinolaryngological infections

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抄録

耳鼻咽喉科領域感染症に対するazithromycin (AZM) の基礎的ならびに臨床的検討を行つた.<BR>体液・組織内移行においてAZMは中耳粘膜, 副鼻腔 (上顎洞, 篩骨洞) 粘膜, 扁桃, 顎下腺へ良好な移行を示し, 長時間組織内濃度が維持された.<BR>総症例180症例に原則として3日間投与した結果, 効果判定が可能であつた139例の有効率は中耳炎73%, 副鼻腔炎77%, 扁桃炎79%, 咽喉頭炎74%など全体として76 %であつた. 細菌学的効果は, 全体で85%の菌消失率であつた. 副作用は1例 (発現率1%), 臨床検査値の異常変動は計8例 (発現率6%) に認められた.<BR>以上の結果から, AZMは中耳炎, 副鼻腔炎, 扁桃炎, 咽喉頭炎などをはじめとする耳鼻咽喉科領域感染症に対して有用性の高い薬剤と考えられた.

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