Influence of Biomaterials on Biomimetic Layer Formation and Cell Adhesion  on the Layer

KIZUKI Takashi, OHGAKI Masataka, NAKAMURA Satoshi, HASHIMOTO Kazuaki, TODA Yoshitomo, YAMASHITA Kimihiro

doi:10.14852/jcersjsuppl.112.0.s792.0

Biocomposite scaffold composed of bone-like apatite and a serum protein was formed on a ceramic hydroxyapatite (HAp) and surface-modified titanium. Formation of the biocomposite scaffold on titanium plate was made possible by alkali-heat treatment. The formed biocomposite scaffold had low crystalinity and had a Ca/P ratio lower than that of synthesized HAp. MC3T3-E1 cells closely adhered to the biocomposite scaffold. The morphology of the biocomposite scaffold depended on the substrate surface. It was suggested that the close adhesion was caused not only by surface roughness but also the composition of the biocomposite scaffold. The adsorbed serum protein on the HAp surface inhibited the deposition of the bone-like apatite. On the other hand, the adsorption of serum protein to the bone-like apatite enhanced cell adhesion. It was suggested that the serum protein operated through a different process to form the cell active biocomposite scaffold. The biocomposite scaffold can be formed on various materials, and it could play a great role in cell adhesion.

Influence of Biomaterials on Biomimetic Layer Formation and Cell Adhesion on the Layer

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