Influence of Biomaterials on Biomimetic Layer Formation and Cell Adhesion on the Layer

DOI
  • KIZUKI Takashi
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ. Industrial Inorganic Chemistry, Graduate School of Engineering, Chiba Institute of Technology
  • OHGAKI Masataka
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ.
  • NAKAMURA Satoshi
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ.
  • HASHIMOTO Kazuaki
    Industrial Inorganic Chemistry, Graduate School of Engineering, Chiba Institute of Technology
  • TODA Yoshitomo
    Industrial Inorganic Chemistry, Graduate School of Engineering, Chiba Institute of Technology
  • YAMASHITA Kimihiro
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ.

説明

Biocomposite scaffold composed of bone-like apatite and a serum protein was formed on a ceramic hydroxyapatite (HAp) and surface-modified titanium. Formation of the biocomposite scaffold on titanium plate was made possible by alkali-heat treatment. The formed biocomposite scaffold had low crystalinity and had a Ca/P ratio lower than that of synthesized HAp. MC3T3-E1 cells closely adhered to the biocomposite scaffold. The morphology of the biocomposite scaffold depended on the substrate surface. It was suggested that the close adhesion was caused not only by surface roughness but also the composition of the biocomposite scaffold. The adsorbed serum protein on the HAp surface inhibited the deposition of the bone-like apatite. On the other hand, the adsorption of serum protein to the bone-like apatite enhanced cell adhesion. It was suggested that the serum protein operated through a different process to form the cell active biocomposite scaffold. The biocomposite scaffold can be formed on various materials, and it could play a great role in cell adhesion.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282680502591104
  • NII論文ID
    130004610308
  • DOI
    10.14852/jcersjsuppl.112.0.s792.0
  • ISSN
    13492756
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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