DAMAGE AND REPAIR OF DNA IN URINARY BLADDER EPITHELIUM OF RATS TREATED WITH N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE
書誌事項
- タイトル別名
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- Damage and Repair of DNA in Urinary Bla
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N-Butyl-N-(4-hydroxybutyl) nitrosamine (BBN), which selectively induced urinary bladder tumors in several experimental animal species, was found to cause damage of DNA in the bladder epithelium. Wistar strain rats were given 100mg/kg of BBN intravesically and killed after 2, 6, 12, 24, or 48hr. DNA damage was examined by measuring the change in sedimentation pattern in an alkaline sucrose gradient. Amount of DNA in each fraction was determined by fluorescence spectrophotometry. At 2hr, the sedimentation profile shifted from heavier (No. 15, control peak) to lighter (Nos. 2∼4) fractions, and the maximum effect appeared at 6hr as a single peak in the lighter fractions. At 12hr, damaged DNA was in the process of repair as two peaks were present, one light and one heavy. At 48hr, the sedimentation profile showed a single peak identical with that of controls indicating complete repair of DNA.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (6), 781-783, 1977
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282680506050688
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- NII論文ID
- 40000528965
- 130006409788
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- NII書誌ID
- AN00045888
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- NDL書誌ID
- 1917535
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可