レチノイン酸の代謝と機能にかかわる遺伝子多型 : ALDH1A2とRARβの場合(<特集>「ビタミンと遺伝子多型」-ビタミンA-)

DOI Web Site
  • 四童子 好廣
    長崎県立大学大学院・人間健康科学研究科・細胞生化学

書誌事項

タイトル別名
  • Single nucleotide polymorphisms involved in metabolism and functions of retinoic acid : in cases of ALDH1A2 and RARβ
  • レチノイン酸の代謝と機能にかかわる遺伝子多型 : ALDH1A2とRARβの場合
  • レチノインサン ノ タイシャ ト キノウ ニ カカワル イデンシ タケイ : ALDH1A2 ト RARv ノ バアイ

この論文をさがす

抄録

Few association studies on vitamin A and genetic polymorphism have been conducted so far, even though brilliant success has been achieved in translational researches on vitamin D receptor or methylene tetrahydrofolate reductase gene polymorphism. Recently, a couple of epoch-making papers have been published in vitamin A and genetic polymorphism field: 1) a common intronic single nucleotide polymorphism (SNP) (rs12591551 A/C) of the aldehyde dehydrogenase 1A2 (ALDH1A2) gene was shown to be associated with individual variations of retinoic acid concentrations in umbilical cord blood, and 2) two common intronic SNPs (rs6800566, rs13070407) of the retinoic acid receptor β (RARβ) gene were shown to be associated with individual variations of adaptive immune responses to measles vaccine. In this mini-review, these 2 pioneering works are introduced and discussed briefly.

収録刊行物

  • ビタミン

    ビタミン 87 (10), 551-556, 2013

    公益社団法人 日本ビタミン学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ