ビタミンB_<12>とtranscobalamin IIの一塩基多型(<特集>「ビタミンと遺伝子多型」-ビタミンB-)

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タイトル別名
  • Polymorphisms of transcobalamin II and vitamin B_<12>
  • ビタミンB₁₂とtranscobalamin Ⅱの一塩基多型
  • ビタミン B ₁ ₂ ト transcobalamin Ⅱ ノ ヒトシオキ タケイ

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抄録

The transport of vitamin B_<12> (B_<12>) from food to cells depends on three B_<12>-binding proteins in mammals, haptcorrin (HC), intrinsic factor (IF), and transcobalamin II (TC II). The serum protein, TC II, transports B_<12> from the ileum to the tissue. The B_<12>-TC II complex (holoTC II) is then taken up into cells by receptor-mediated endocytosis. To date, at least 20 polymorphisms in the gene encoding TC II have been identified. Recently, the potential influence of TC II polymorphisms on serum holoTC II, serum B_<12>, methyl maronic acid (MMA), and total homocysteine (tHcy) status has been reported. This article summarizes the relationship between TC II polymorphisms and B_<12>-related markers, races, diseases, and structural changes in the protein.

収録刊行物

  • ビタミン

    ビタミン 87 (8), 430-434, 2013

    公益社団法人 日本ビタミン学会

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