D-アミノ酸代謝酵素システムの機能と構造に関する疾患酸素学研究

福井 清

doi:10.20632/vso.86.2_63

書誌事項

タイトル別名

Disease-targeted Enzymology on the Function and Structure of D-Amino Acid Metabolic System
D-アミノ酸代謝酵素システムの機能と構造に関する疾患酵素学研究
D-アミノサンタイシャコウソシステムノキノウトコウゾウニカンスルシッカンコウソガクケンキュウ

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説明

D-Amino acid oxidase (DAO) has been proposed to be involved in the decreased glutamatergic neurotransmission in schizophrenia and the modulation of its activity is expected to be therapeutic. Here we show the inhibitory effect of antipsychotic drugs, chlorpromazine and risperidone, on human DAO activity. In search of the pathophysiological role of DAO, we analyzed its distribution in brain. The immunoreactivity for DAO was detected in glial cells of rhombencephalon and in choroid plexus (CP) in the human brain. Furthermore, higher level of DAO expression was observed in schizophrenic CP epithelial cells. These results suggest that DAO expression level is altered in schizophrenia and the increase in DAO expression is involved in aberrant D-amino acid metabolism. In particular, gene expression of DAO in CP suggests that DAO may regulate D-amino acid concentration by modulating the cerebrospinal fluid, and may be regarded as a potential therapeutic target for schizophrenia.

収録刊行物

ビタミン

ビタミン 86 (2), 63-73, 2012

公益社団法人日本ビタミン学会

キーワード

詳細情報詳細情報について

CRID: 1390282680678553472

NII論文ID: 110009419211

NII書誌ID: AN00207833

DOI: 10.20632/vso.86.2_63

ISSN: 2424080X; 0006386X

NDL書誌ID: 023542612

Web Site: http://id.ndl.go.jp/bib/023542612; https://ndlsearch.ndl.go.jp/books/R000000004-I023542612; https://search.jamas.or.jp/link/ui/2012187963

本文言語コード: ja

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