A case of anemia gravis newborn suspected of fetomaternal transfusion (FMT) syndrome

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  • 母児間輸血症候群fetomaternal transfusion syndrome（FMT）が疑われた新生児重症貧血の1‍症例

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A male infant with a birth weight of 2,590 g and Hb of 5.4 g/dl required blood transfusion. His blood type was interpreted as A RhD+ by the ABO and Rh factor test. He was subjected to cross matching with red cell concentrate (RCC) of blood type A RhD+, and the results showed incompatible reaction. This result indicates that he has inherited antibodies from his mother. His mother’s blood type is O RhD+ with no irregular antibodies. Her anti-A antibody titer was 512 times that of IgG, with HbF of 0.8% and AFP of 6,781 ng/ml. We suspected fetomaternal transfusion (FMT) syndrome owing to the transfer of the fetus’ blood to the mother’s body. It was considered that the anti-A antibody titer became high; therefore, we assumed that a large amount of anti-A antibody had entered the blood of the infant. Anti-A antibody titer of fetus’ was 8 times that of IgG. We again carried out cross matching of his blood with RCC of blood type O RhD+, and the result showed compatible reaction. After that, the infant became better and was discharged from the hospital. FMT can occur during pregnancy; thus, we must pay attention to severe cases.

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