書誌事項
- タイトル別名
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- Relationship between Serum Ascorbic Acid, Serum Type IV Collagen and Urinary Albumin Excretion in Diabetes
- 糖尿病患者における血清アスコルビン酸と4型コラーゲンおよび尿中アルブミン排泄量の検討
- トウニョウビョウ カンジャ ニ オケル ケッセイ アスコルビンサン ト 4ガタ
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抄録
Capillary basement membrane thickening is a characteristic of diabetic microangiopathy. Type IV collagen is the major component of basement membrane. To elucidate the pathogenesis of diabetic nephropathy, we investigated serum type IV collagen and serum ascorbic acid in non-insulin-dependent diabetes mellitus (NIDDM) (n=37) and in normal subject s (n=14). Serum ascorbic acid level was lower in NIDDM than in normal subjects. Serum type IV collagen level was higher in NIDDM than in normal subjects. There was a significant positive correlation between serum type IV collagen and HbA_<IC> in poorly controlled diabetes (HbA_<IC>>8%) (p<0.05). A significant negative correlation was found between serum type IV collagen and serum ascorbic acid (p<0.05). A significant positive correlation was found between serum type IV collagen and urinary albumin excretion in patients with microalbuminuria (U-alb>30 mg/g・Cr) in NIDDM. In conclusion, serum type IV collagen is helpful as a early indicator of nephropathy.
収録刊行物
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- ビタミン
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ビタミン 70 (5-6), 235-240, 1996
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680738606464
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- NII論文ID
- 110002845548
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 3977232
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可