A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks
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- Aoki Mami
- Healthcare Products Development Center, KYOWA HAKKO BIO CO., LTD.
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- Mochizuki Masahiro
- Gotemba Laboratory, BoZo Research Center Inc.
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- Okamura Toshiya
- Gotemba Laboratory, BoZo Research Center Inc.
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- Hatayama Kazuhisa
- Gotemba Laboratory, BoZo Research Center Inc.
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- Nakamura Atsushi
- Gotemba Laboratory, BoZo Research Center Inc.
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- Morishita Koji
- Public Relations Department, KYOWA HAKKO BIO CO., LTD.
書誌事項
- 公開日
- 2014
- DOI
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- 10.2131/fts.1.63
- 公開者
- 一般社団法人 日本毒性学会
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説明
To investigate the safety of L-alanine, male and female Sprague-Dawley strain SPF rats [Crj:CD(SD)IGS] were administered L-alanine at 2,000 mg/kg/day by gavage for 4 weeks. After the end of the dosing period, reversibility was assessed following a 2-week recovery period. In the results, there were no toxicologically significant changes caused by L-alanine in general condition, body weight, food consumption, ophthalmology, hematology, blood chemistry, organ weight or at necropsy. In urinalysis, increased number of animals showing urine protein-positive or phosphate salt was observed in males and females. In addition, urine volume was significantly increased in males. In histopathological examination, squamous cell hyperplasia in the limiting ridge in the stomach was observed in males and females. These changes were reduced or no longer observed after the 2-week recovery period and thus were reversible changes. These results suggest that repeated oral administration of L-alanine at 2,000 mg/kg/day for 4 weeks is well tolerated in male and female rats.
収録刊行物
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- Fundamental Toxicological Sciences
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Fundamental Toxicological Sciences 1 (2), 63-72, 2014
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390282680739699328
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- NII論文ID
- 130005083336
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- DOI
- 10.2131/fts.1.63
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- ISSN
- 2189115X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
