Diagnostic criteria for autoimmune pancreatitis protein electrophoresis became the beginning of discovery

DOI Web Site 6 References
  • Sugano Mitsutoshi
    Department of Laboratory Medicine, Shinshu University Hospital
  • Uehara Takeshi
    Department of Laboratory Medicine, Shinshu University school of Medicine
  • Ishimine Nau
    Department of Laboratory Medicine, Shinshu University Hospital
  • Usami Yoko
    Department of Laboratory Medicine, Shinshu University Hospital
  • Kawasaki Kenji
    Department of Laboratory Medicine, Shinshu University Hospital
  • Hamano Hideaki
    Department of Medical Informatics, Shinshu University Hospital
  • Honda Takayuki
    Department of Laboratory Medicine, Shinshu University school of Medicine

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  • 電気泳動検査が発見の端緒となった自己免疫性膵炎の診断基準

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Serum protein electrophoresis is a useful test for the clinical detection of M-proteins that indicate qualitative serum protein abnormalities as well as changes in pathological conditions based on quantitative changes in five fractions. The results of routine laboratory work led us to report on a pattern of IgG4 concentration increase based on the discovery of specific β-γ bridging that demonstrated characteristic elevation at the first-γ position (unlike normal β-γ bridging). Furthermore, the routine work assisted in the discovery of autoimmune pancreatitis as an IgG4-related disease. Subsequently, in the year 2006, elevated serum IgG4 level (≧135 mg/dL) was adopted as a clinical diagnostic criteria for autoimmune pancreatitis, and serum IgG4 measurements were accepted for coverage by insurance. In this study, we introduce a typical case of IgG4-related disease and commented about the diagnostic criteria.

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