書誌事項
- タイトル別名
-
- J164015 Structuring of scaffold and its effect on cell adhesion
抄録
Regenerative medicine attracts attention as cutting-edge medical technology. One of the problems is how to separate the cultured cells from the culture scaffold without damage. The purpose of this study is to produce an easily dislodged cultured cell applying microstructure on the scaffold. A die was fabricated by etching Si substrate through a mask of self-assembled silica particles of which diameter were 1 μm or 5 μm. To make the environment similar to in vivo considering the oxygen permeability, the structure was copied to polydimethylsiloxane scaffold The adhesion force of cells after cultivation was measured directly peering off the cells with an AFM cantilever set on a micromanipulator. The deflection of the cantilever when the cell peered off from the scaffold was measured from the captured image and peering force was calculated. It was found that adhesion force can be decreased to 164 μN while that on flat media was 306 μN.
収録刊行物
-
- 年次大会
-
年次大会 2012 (0), _J164015-1-_J164015-4, 2012
一般社団法人 日本機械学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680818296576
-
- NII論文ID
- 110009994988
-
- ISSN
- 24242667
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可