P-15 New hericenones including a protective agent against ER stress-dependent Neuro2a cell death from the medicinal mushroom of Hericium erinaceum(Poster Presentation)

DOI

Bibliographic Information

Other Title
  • P-15 ヤマブシタケ(Hericium erinaceum)から得られた小胞体ストレスによる細胞死阻害物質(ポスター発表の部)

Description

The importance of the endoplasmic reticulum (ER) in triggering a specific program of cell death has been recently reported. By triggering apoptosis on neural cells, ER-stress is a major cause of neurodegenerating disease such as Alzheimer disease. The demand for new protective substances to the ER-stress-dependent cell death prompted us to screen the protective activity of mushrooms. On the course of the screening, we isolated new hericenones, 3-hydroxy-hericenone F as a protective agent, along with related compounds, hericenone I and J. The structures of hericenones were determined by NMR and MS spectra. The structure of 3-hydroxy hericenone was elucidated as (8-formyl-3-hydroxy-5-methoxy-2-methyl-2-(4'-methyl-2'-oxopent-3'-enyl) chroman-7-yl) methyl palmitate, which had one additional hydroxy group compared to hericenone F. 3-Hydroxy-hericenone F showed the protective activity dose-dependently, however hericenones F, I and J did not have any activity at the concentration of 10μg/mL. Therefore, we suggested that the hydroxy group of 3-hydroxy-hericenone F was important for the protective activity. This is the first report of a new hericenone which has the protective activity against ER stress-dependent cell death. The further study using more hericenones is needed for the understanding of the structure-activity relationship.

Journal

Details 詳細情報について

  • CRID
    1390282681055336576
  • NII Article ID
    110007066744
  • DOI
    10.24496/tennenyuki.50.0_309
  • ISSN
    24331856
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top