書誌事項
- タイトル別名
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- Field Survey of the Anticancer Drug Contamination in the Preparation Environment<br/>~Usefulness of the 5-FU Monitoring by the Coupon Method~
- 抗がん剤調製環境における汚染調査 : クーポン法による5-FUモニタリングの有用性
- コウガンザイ チョウセイ カンキョウ ニ オケル オセン チョウサ : クーポンホウ ニ ヨル 5-FU モニタリング ノ ユウヨウセイ
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抄録
For medical professionals involved in cancer chemotherapy, occupational exposure of anticancer agents is considered a health risk. Education about the handling of anticancer drugs and proper use of protective equipment are important for reducing occupational exposure of anticancer drugs. Furthermore, monitoring of the contamination level of anticancer drugs is important for determining the propriety of anti-contamination methods. Cyclophosphamide (CPA) has been used as the standard drug of the contamination level; however, it is rarely detected because of the disparity between drug preparation frequency and consumption, and use of a closed system. Therefore, we chose 5-fluorouracil (5-FU) as the standard drug and attempted to monitor its contamination levels by sampling using drug absorption sheets (the coupon method). We measured contamination levels inside a biological safety cabinet (BSC) and at its lower floor, and at a preparation worktable, nurses' station worktable, its lower floor and floor of the hospital room in a chemotherapy room for outpatients of the Iwate Medical University Hospital for 3 time periods. 5-FU was detected in 72% of the coupons (n=108), while CPA was detected in only 7% of the coupons (n=108). Monitoring of 5-FU contamination levels by using the coupon method was considered useful for evaluating anti-contamination method and the contamination process.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 134 (6), 751-756, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681103525504
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- NII論文ID
- 130004427990
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC2cjot1KjtQ%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 025583408
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- PubMed
- 24882652
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可