Nucleoside Qおよび類縁体の化学と生物活性

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タイトル別名
  • Chemistry and Biological Activity of Nucleoside Q and Its Analogs
  • Nucleoside Q オヨビ ルイエンタイ ノ カガク ト セイブツ カッ

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説明

Nucleoside Q was found in the first position of anticodon in some transfer ribonucleic acids (tRNAs). Total synthesis of the nucleoside Q and its diastereomer made it possible to determine relative and absolute configurations of nucleoside Q. An unusual posttranscriptional modification mechanism in the biosynthesis of nucleoside Q was found by Nishimura et al. by using our synthetic nucleoside Q derivatives. A deficiency of Q in tRNAs is related to tumor growth. Some cancer cells contain tRNAs having G in place of Q ; Q base administered can be incorporated into these tRNAs. Two anticancer antibiotics having such 7-deazapurine nucleus as cadeguomycin and kanagawamicin were found and the former was synthesized.

収録刊行物

  • 薬学雑誌

    薬学雑誌 104 (4), 317-324, 1984

    公益社団法人 日本薬学会

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